Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 K1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
J Gastroenterol. 2010 Jul;45(7):713-20. doi: 10.1007/s00535-010-0216-6. Epub 2010 Feb 20.
Double-balloon endoscopy (DBE) examinations are not yet widely accepted as routine procedures for examining the small bowel of patients with Crohn's disease (CD).
To evaluate the feasibility and usefulness of DBE for CD in tertiary-care hospitals.
Between July 2004 and September 2008, 1444 DBE procedures were performed for 704 patients in 6 tertiary-care hospitals. Patient profile, indication, diagnosis and treatment of DBE were evaluated using a multicenter database.
DBE examinations were most frequently performed in 75 patients with CD, corresponding to 10.5% of all the patients examined by DBE. Fifty patients were diagnosed with CD before DBE, while DBE was performed for the diagnosis of 25 new CD patients. Small bowel lesions were often detected even when the terminal ileum was not involved. In the 75 patients, 21 patients were asymptomatic at the time of DBE examinations. Active inflammatory lesions were detected in 51.2% of the CD patients, and were even detected in 33.3% of the asymptomatic CD patients. The treatment was altered in 53.3% of the CD patients after the DBE evaluation. No severe complications were experienced.
DBE procedures can be safely performed in patients with CD and should be considered for the precise evaluation of and to determine the treatment strategy for CD.
双气囊内镜（DBE）检查尚未被广泛接受为克罗恩病（CD）患者小肠检查的常规程序。
评估 DBE 在三级保健医院用于 CD 的可行性和实用性。
在 2004 年 7 月至 2008 年 9 月期间，6 家三级保健医院对 704 例患者进行了 1444 例 DBE 检查。使用多中心数据库评估了 DBE 的患者特征、适应证、诊断和治疗情况。
DBE 检查最常用于 75 例 CD 患者，占所有接受 DBE 检查患者的 10.5%。50 例患者在 DBE 检查前被诊断为 CD，而 25 例新的 CD 患者则进行了 DBE 检查以明确诊断。即使末端回肠不受累及，也经常能发现小肠病变。在 75 例患者中，有 21 例患者在 DBE 检查时无症状。51.2%的 CD 患者存在活动性炎症性病变，甚至在 33.3%的无症状 CD 患者中也能发现活动性炎症性病变。在 DBE 评估后，53.3%的 CD 患者改变了治疗方案。无严重并发症发生。
DBE 检查可安全用于 CD 患者，应考虑用于对 CD 进行精确评估并确定治疗策略。
