Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, People's Republic of China.
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.
BMC Gastroenterol. 2023 Jul 20;23(1):247. doi: 10.1186/s12876-023-02839-8.
To assess the efficacy of double-balloon endoscopy (DBE) for the detection of small-bowel strictures in Crohn's disease (CD).
This tertiary-referral hospital cohort study was conducted between January 2018 and May 2022. CD patients with symptoms of small-bowel stricture were enrolled sequentially. All of the patients were subjected to both computed tomography enterography (CTE) and DBE, and their symptoms of stricture were assessed using the Crohn's Disease Obstructive Score (CDOS). The diagnostic yield of DBE was compared to that of CTE, and the relationship between the DBE findings and CDOS was investigated. The factors influencing the DBE diagnosis were examined using Cox regression analysis.
This study included 165 CD patients. The CDOS scores were higher in 95 patients and lower in 70 patients. DBE detected 92.7% (153/165) and CTE detected 85.5% (141/165) of the strictures. The DBE diagnostic yields were 94.7% (90/95) in the high CDOS patients and 91.4% (64/70) in the low CDOS patients (P = 0.13). Patients with a history of abdominal surgery and abscess had a lower diagnosis rate in the multivariate analysis.
DBE has been demonstrated to be an efficient diagnostic method for detecting small bowel strictures in CD patients. Additionally, there was no difference in the diagnostic yields between patients with low and high obstructive scores.
评估双气囊内镜（DBE）检测克罗恩病（CD）小肠狭窄的疗效。
这是一项 2018 年 1 月至 2022 年 5 月在三级转诊医院进行的队列研究。连续纳入有小肠狭窄症状的 CD 患者。所有患者均接受计算机断层扫描肠造影术（CTE）和 DBE 检查，并使用克罗恩病梗阻评分（CDOS）评估其狭窄症状。比较 DBE 和 CTE 的诊断率，并研究 DBE 结果与 CDOS 的关系。使用 Cox 回归分析检查影响 DBE 诊断的因素。
本研究纳入 165 例 CD 患者。95 例患者 CDOS 评分较高，70 例患者 CDOS 评分较低。DBE 检测到 165 例中的 92.7%（153/165），CTE 检测到 165 例中的 85.5%（141/165）。高 CDOS 患者的 DBE 诊断率为 94.7%（90/95），低 CDOS 患者为 91.4%（64/70）（P=0.13）。有腹部手术和脓肿病史的患者在多变量分析中诊断率较低。
DBE 已被证明是一种有效的诊断方法，可用于检测 CD 患者的小肠狭窄。此外，低梗阻评分和高梗阻评分患者的诊断率无差异。
