Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
Chemistry. 2010 Apr 6;16(13):4010-7. doi: 10.1002/chem.200902842.
As less attention has been focussed on the design of highly efficient palladium precatalysts to ensure the smooth formation of the active catalyst for metal-mediated cross coupling reactions, we herein demonstrate that combining the bulky N-heterocyclic carbene (NHC) 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr) with cyclopalladated acetanilide as the optimal palladium precatalyst leads to superior catalytic activity compared with the state-of-the-art NHC-Pd catalysts. The complex was discovered through the evaluation of a small, rationally designed library of NHC-palladacycles prepared by a novel, practical and atom-economic method, the direct reaction of IPrHCl with palladacycle acetate dimers.
由于人们对高效钯前催化剂的设计关注较少，无法确保用于介导金属交叉偶联反应的活性催化剂的顺利形成，因此我们在此证明，将大位阻的 N-杂环卡宾（NHC）1,3-双（2,6-二异丙基苯基）咪唑-2-亚基（IPr）与环钯化乙酰胺结合作为最佳钯前催化剂，与最先进的 NHC-Pd 催化剂相比，具有更高的催化活性。该配合物是通过对一小部分通过新型、实用且原子经济性的方法——IPrHCl 与钯环二聚体的直接反应制备的、经过合理设计的 NHC-钯环的文库进行评估而发现的。
