在电休克治疗过程中，抑郁症病情的改善与神经垂体激素运载蛋白释放的改变无关。

Improvement in depressive illness is not associated with altered release of neurophysins over a course of ECT.

作者信息

Scott A I, Shering P A, Legros J J, Whalley L J

机构信息

University Department of Psychiatry, Royal Edinburgh Hospital, U.K.

出版信息

Psychiatry Res. 1991 Jan;36(1):65-73. doi: 10.1016/0165-1781(91)90118-9.

DOI:10.1016/0165-1781(91)90118-9

PMID:2017524

Abstract

The hypothesis that the release of vasopressin-associated neurophysin (hNpI) or oxytocin-associated neurophysin (hNpII) is modified by a course of electroconvulsive therapy (ECT) was tested by the measurement of serum neurophysins before and after the first and last ECTs given to 17 unipolar depressed patients. Neither basal nor ECT-induced neurophysin release changed between the first and last ECTs. Data from the present study were combined with data from a previous published study to provide a sample of 29 unipolar depressed patients. In this extended sample, the release of hNpII after the first ECT was significantly correlated with improvement in symptoms of depression over a course of ECT as measured by the Hamilton Rating Scale for Depression and the Montgomery-Asberg Depression Rating Scale.

摘要

通过测量17例单相抑郁症患者首次和末次电休克治疗（ECT）前后的血清神经垂体素，来检验血管加压素相关神经垂体素（hNpI）或催产素相关神经垂体素（hNpII）的释放是否会因电休克治疗疗程而改变。首次和末次ECT之间，基础神经垂体素释放及ECT诱导的神经垂体素释放均未发生变化。本研究的数据与之前发表的一项研究的数据相结合，得到了一个包含29例单相抑郁症患者的样本。在这个扩大的样本中，首次ECT后hNpII的释放与ECT疗程中抑郁症状的改善显著相关，抑郁症状改善程度通过汉密尔顿抑郁量表和蒙哥马利-阿斯伯格抑郁量表进行测量。