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[离子通道病与遗传性心律失常]

[Ion channelopathies and inherited arrhythmia].

作者信息

Feng Ming-jun, Chu Hui-min

机构信息

Ninbo First Hospital, Affiliated Medical of Ninbo University, Ninbo, China.

出版信息

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Jan;39(1):97-102. doi: 10.3785/j.issn.1008-9292.2010.01.017.

Abstract

Ion channelopathies are the mainly etiopathogenisis of inherited arrhythmia. Those arrhythmia syndromes are commonly caused by ion channel gene mutation, which can be classified as sodium,potassium and calcium ion channel mutation.Changes in the genes encoding for cardiac ion channel subunits produce modification in the function of the channels, and cause the dysfunctions of cardiac electrical activity; and the clinical manifestation is malignant arrhythmia.

摘要

离子通道病是遗传性心律失常的主要病因。那些心律失常综合征通常由离子通道基因突变引起,可分为钠、钾和钙离子通道突变。编码心脏离子通道亚基的基因变化会导致通道功能改变,进而引起心脏电活动功能障碍;其临床表现为恶性心律失常。

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