Chemistry Department, Acadia University, Wolfville, NS B4P 2R6, Canada.
Org Lett. 2010 Mar 19;12(6):1172-5. doi: 10.1021/ol902907r.
Gel mobility assays were used to establish that some members of the jadomycin family of natural products act as DNA cleaving agents. Moreover, it was found that subtle structural changes generated through the use of precursor-directed biosynthesis lead to marked effects on the DNA-damaging properties of these glycosylated polyketide-derived natural products.
凝胶迁移实验被用来证实一些天然产物的杰德霉素家族成员具有 DNA 切割剂的作用。此外，人们发现，通过使用前体定向生物合成产生的细微结构变化，会对这些糖基化聚酮衍生的天然产物的 DNA 损伤特性产生显著影响。
