Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland.
Gynecol Endocrinol. 2010 Aug;26(8):582-9. doi: 10.3109/09513591003632043.
This study was designed to evaluate cumulative live birth rates after an in vitro fertilisation (IVF) programme in polycystic ovary syndrome (PCOS) women.
IVF outcomes of 66 women with PCOS diagnosed via Rotterdam criteria, who failed to conceive after ovulation induction, were compared with 106 women with tubal factor infertility. One hundred and twenty-five cycles were analysed in the PCOS group and 225 cycles in the control group (1-4 cycles per woman). Results of frozen-thawed cycles, occurrence of ovarian hyperstimulation syndrome (OHSS) and drop-outs were also included.
Despite a lower pregnancy rate among women with PCOS versus controls, the cumulative baby take-home rate did not differ between the groups (48.5% and 44.3%). The first cycle was the most successful cycle for living birth rate in PCOS group. One-third of PCOS women, who did not continue after unsuccessful treatment, had more miscarriage but not more OHSS compared to those who continued.
Although the baby take-home rate was similar among women with PCOS, and controls, the outcomes of consecutive cycles were not equal. Cumulative data give more realistic information than pooled cycles.
本研究旨在评估多囊卵巢综合征（PCOS）患者体外受精（IVF）方案后的累积活产率。
通过 Rotterdam 标准诊断为 PCOS 的 66 名排卵诱导后未能受孕的妇女的 IVF 结局与 106 名输卵管因素不孕的妇女进行比较。对 PCOS 组的 125 个周期和对照组的 225 个周期（每个妇女 1-4 个周期）进行了分析。还包括冷冻解冻周期的结果、卵巢过度刺激综合征（OHSS）的发生和脱落率。
尽管 PCOS 患者的妊娠率低于对照组，但两组的累积婴儿抱回家率无差异（48.5%和 44.3%）。对于活产率，PCOS 组的第一个周期是最成功的周期。与继续治疗的患者相比，三分之一在治疗失败后未继续治疗的 PCOS 患者流产更多，但 OHSS 并不多。
尽管 PCOS 患者与对照组的婴儿抱回家率相似，但连续周期的结果并不相等。累积数据比合并周期提供更现实的信息。
