• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Analysis of inhibition of topoisomerase IIalpha and cancer cell proliferation by ingenolEZ.依尼醇 EZ 对拓扑异构酶 IIalpha 的抑制作用及其对癌细胞增殖的影响分析。
Cancer Sci. 2010 Feb;101(2):374-8. doi: 10.1111/j.1349-7006.2009.01408.x.
2
Diterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus.甘遂根中的二萜类化合物及其对非洲爪蟾细胞分裂的体外作用。
J Nat Prod. 2002 Sep;65(9):1246-51. doi: 10.1021/np0200921.
3
The water expelling effect evaluation of 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol and ingenol on H22 mouse hepatoma ascites model and their content differences analysis in Euphorbia kansui before and after stir-fried with vinegar by UPLC.水飞蓟宾和京尼平苷酸对 H22 肝癌腹水模型的排水作用评价及其醋炙前后在甘遂中的含量差异分析
J Ethnopharmacol. 2021 Mar 1;267:113507. doi: 10.1016/j.jep.2020.113507. Epub 2020 Oct 22.
4
3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces apoptosis in intestinal epithelial cells of rats via mitochondrial pathway.3-O-(2'E,4'Z-癸二烯酰基)-20-O-乙酰基大戟醇通过线粒体途径诱导大鼠肠上皮细胞凋亡。
J Ethnopharmacol. 2015 Nov 4;174:331-8. doi: 10.1016/j.jep.2015.08.036. Epub 2015 Aug 28.
5
Ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry analysis of the impact of processing on toxic components of Kansui Radix.超高效液相色谱-四极杆/飞行时间质谱法分析炮制对甘遂毒性成分的影响
BMC Complement Altern Med. 2016 Feb 24;16:73. doi: 10.1186/s12906-016-1039-7.
6
Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials.新型苯并[c]菲啶NK314对拓扑异构酶IIα的抑制作用及G2期细胞周期阻滞，NK314目前正处于临床试验阶段。
Mol Cancer Ther. 2007 May;6(5):1501-8. doi: 10.1158/1535-7163.MCT-06-0780.
7
Three antinematodal diterpenes from Euphorbia kansui.来自甘遂的三种抗线虫二萜类化合物。
Biosci Biotechnol Biochem. 2007 Apr;71(4):1086-9. doi: 10.1271/bbb.60677. Epub 2007 Apr 7.
8
Daurinol, a catalytic inhibitor of topoisomerase IIα, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phase.大豆苷元，一种拓扑异构酶IIα的催化抑制剂，通过使细胞周期停滞于S期来抑制SNU - 840卵巢癌细胞的增殖。
Int J Oncol. 2014 Aug;45(2):558-66. doi: 10.3892/ijo.2014.2442. Epub 2014 May 16.
9
Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase IIα activity.桑叶中含酚的有机提取物通过 G2/M 期阻滞、诱导细胞凋亡和抑制拓扑异构酶 IIα 活性来抑制 HepG2 肝癌细胞。
J Med Food. 2010 Oct;13(5):1045-56. doi: 10.1089/jmf.2010.1021.
10
Toxicity Reduction of Stir-Fried with Vinegar Based on Conversion of 3--(2',4'-Decadi-enoyl)-20--acetylingenol.基于 3--(2',4'-十二烯酰基)-20--乙酰姜烯醇转化的醋炒减毒
Molecules. 2019 Oct 22;24(20):3806. doi: 10.3390/molecules24203806.

引用本文的文献

1
Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II.作为靶向拓扑异构酶I和II的抗癌剂的铜配合物
Cancers (Basel). 2020 Oct 5;12(10):2863. doi: 10.3390/cancers12102863.
2
Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng).中药本草典籍《神农本草经》中常用草药的研究进展
J Tradit Complement Med. 2012 Jan;2(1):6-26. doi: 10.1016/s2225-4110(16)30066-9.
3
3EZ,20Ac-ingenol, a catalytic inhibitor of topoisomerases, downregulates p-Akt and induces DSBs and apoptosis of DT40 cells.3EZ、20Ac-ingenol 是拓扑异构酶的催化抑制剂，可下调 p-Akt 并诱导 DT40 细胞发生 DSBs 和凋亡。
Arch Pharm Res. 2013 Aug;36(8):1029-38. doi: 10.1007/s12272-013-0108-4. Epub 2013 Apr 18.

本文引用的文献

1
Isolation and characterization of methyl esters and derivatives from Euphorbia kansui (Euphorbiaceae) and their inhibitory effects on the human SGC-7901 cells.大戟科大戟属甘遂中甲酯及其衍生物的分离、表征及其对人SGC - 7901细胞的抑制作用。
J Pharm Pharm Sci. 2005 Sep 27;8(3):528-35.
2
Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor.二萜类化合物（拓扑异构酶II抑制剂）对细胞增殖的抑制作用
Bioorg Med Chem. 2006 Mar 15;14(6):2048-51. doi: 10.1016/j.bmc.2005.10.059. Epub 2005 Nov 28.
3
Ingenol derivatives inhibit proliferation and induce apoptosis in breast cancer cell lines.
Eur J Gynaecol Oncol. 2005;26(5):526-30.
4
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.抑制DNA解连环作用而非DNA损伤，会使细胞停滞在中期。
Mol Cell. 2004 Sep 24;15(6):977-90. doi: 10.1016/j.molcel.2004.08.018.
5
Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.在人肺癌细胞系中鉴定与DNA损伤G2检查点无关的解连环G2检查点损伤。
Cancer Res. 2004 Jul 15;64(14):4826-32. doi: 10.1158/0008-5472.CAN-04-0871.
6
Selective inhibition of the growth of cancer cells by diterpenes selected with embryonic cells of Xenopus.
Cell Biol Int. 2004;28(3):179-84. doi: 10.1016/j.cellbi.2003.11.017.
7
Ethanolic extracts of Euphorbia and other ethnobotanical species as inhibitors of human tumour cell growth.
Phytomedicine. 2003 Jan;10(1):53-8. doi: 10.1078/094471103321648665.
8
The human decatenation checkpoint.人类解连环检查点。
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12044-9. doi: 10.1073/pnas.221430898. Epub 2001 Oct 2.
9
Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway.大戟醇酯通过一条独立于AP-1和核因子κB的途径诱导Jurkat细胞凋亡。
Chem Biol. 2001 Aug;8(8):767-78. doi: 10.1016/s1074-5521(01)00048-5.
10
A robotics-based automated assay for inorganic and organic phosphates.一种基于机器人技术的无机和有机磷酸盐自动检测方法。
Anal Biochem. 1999 Jun 15;271(1):29-35. doi: 10.1006/abio.1999.4100.

依尼醇 EZ 对拓扑异构酶 IIalpha 的抑制作用及其对癌细胞增殖的影响分析。

Analysis of inhibition of topoisomerase IIalpha and cancer cell proliferation by ingenolEZ.

机构信息

Department of Chemistry, College of Humanities and Sciences, Nihon University, Tokyo, Japan.

出版信息

Cancer Sci. 2010 Feb;101(2):374-8. doi: 10.1111/j.1349-7006.2009.01408.x.

DOI:10.1111/j.1349-7006.2009.01408.x
PMID:20175785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11158357/
Abstract

We previously reported that many ingenol compounds derived from Euphorbia kansui exhibit topoisomerase inhibitory activity and/or inhibitory activity of cell proliferation. The inhibitory effects of 20-O-(2'E,4'Z-decadienoyl) ingenol and 3-O-(2'E,4'Z-decadienoyl)-ingenol among these compounds on topoisomerase II activity and on the cell proliferative activity and arrest phase of the cell cycle were studied using a mouse breast cancer (MMT) cell line. Although 20-O-ingenolEZ exerted inhibitory effects on both topoisomerase II activity and cell proliferative activity, 3-O-ingenolEZ exerted inhibitory activity on neither. The 20-O-ingenolEZ-induced cell arrest of MMT-cell proliferation led to a cell cycle arrest in the G2/M phase. Topoisomerase II inhibition can be divided into the poison and catalytic inhibitor types. A checkpoint mechanism is activated when cells are treated with these topoisomerase II inhibitors. Poison-type inhibition occurs via induction of the DNA damage checkpoint and the catalytic-type inhibition occurs via induction of the DNA-decatenation checkpoint, suggestive of distinct checkpoint reactions. 20-O-ingenolEZ inhibited topoisomerase IIalpha activity through inhibition of ATPase, and induced DNA-decatenation checkpoint without signaling for phosphorylation of H2AX.

摘要

我们之前报道过，许多来源于大戟属植物甘遂的 ingenol 类化合物具有拓扑异构酶抑制活性和/或细胞增殖抑制活性。本研究选用小鼠乳腺癌（MMT）细胞系，研究了这些化合物中的 20-O-(2'E,4'Z-癸二烯酰基） ingenol 和 3-O-(2'E,4'Z-癸二烯酰基）-ingenol 对拓扑异构酶 II 活性、细胞增殖活性和细胞周期停滞期的抑制作用。虽然 20-O-ingenolEZ 对拓扑异构酶 II 活性和细胞增殖活性均具有抑制作用，但 3-O-ingenolEZ 则没有。20-O-ingenolEZ 诱导 MMT 细胞增殖停滞导致细胞周期停滞在 G2/M 期。拓扑异构酶 II 抑制剂可分为毒剂型和催化抑制剂型。当细胞用这些拓扑异构酶 II 抑制剂处理时，会激活检验点机制。毒剂型抑制通过诱导 DNA 损伤检验点发生，而催化型抑制则通过诱导 DNA 解链检验点发生，提示存在不同的检验点反应。20-O-ingenolEZ 通过抑制 ATPase 抑制拓扑异构酶 IIalpha 活性，并诱导 DNA 解链检验点发生，而不引发 H2AX 的磷酸化信号。