Institutes of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
J Biomed Sci. 2010 Feb 23;17(1):12. doi: 10.1186/1423-0127-17-12.
The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. We aimed to examine whether the length of (GT)(n) repeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL.
A total of 183 consecutive firstever ischemic stroke inpatients and 164 non-stroke patients were screened for the length of (GT)(n) repeats in HO-1 promoter. The long (L) and short (S) genotype are defined as the averaged repeat number >26 and <==26, respectively.
Stroke patients tended to have more proportions of hypertension, diabetics and genotype L, than those of genotype S. Patients with genotype L of HO-1 gene promoter have higher stroke risk in comparison with genotype S especially in dyslipidemia individuals. The significant differences on stroke risk in multivariate odds ratios were found especially in people with low HDL-C levels.
Subjects carrying longer (GT)(n) repeats in HO-1 gene promoter may have greater susceptibility to develop cerebral ischemic only in the presence of low HDL-C, suggesting the protective effects in HO-1 genotype S in the process of ischemic stroke, particularly in subjects with poor HDL-C status.
血红素加氧酶 (HO)-1 基因启动子的微卫星多态性与易感性缺血性事件有关，包括冠心病、心肌梗死和外周血管疾病。我们旨在研究 HO-1 基因启动子中 (GT)(n) 重复序列的长度是否与 CAD 危险因素患者的缺血性中风有关，尤其是 HDL 水平较低的患者。
共筛选了 183 例首次缺血性中风住院患者和 164 例非中风患者的 HO-1 启动子中 (GT)(n) 重复序列的长度。长 (L) 和短 (S) 基因型定义为平均重复数 >26 和 <==26。
与基因型 S 相比，中风患者更有可能具有更多的高血压、糖尿病和基因型 L 的比例。与基因型 S 相比，HO-1 基因启动子基因型 L 的患者发生中风的风险更高，尤其是在血脂异常个体中。在多变量优势比中发现了显著的中风风险差异，特别是在 HDL-C 水平较低的人群中。
在存在低 HDL-C 的情况下，携带 HO-1 基因启动子中较长 (GT)(n) 重复序列的受试者可能更容易发生脑缺血，这表明 HO-1 基因型 S 在缺血性中风过程中具有保护作用，尤其是在 HDL-C 状态不佳的受试者中。
