Nøjgaard Camilla, Bendtsen Flemming, Matzen Peter, Becker Ulrik
Department of Gastroenterology, Hvidovre Hospital, Kettegård Alle 30, DK-2650 Hvidovre, Denmark.
Dan Med Bull. 2010 Jan;57(1):A4103.
The change in aetiology over time of acute and chronic pancreatitis has been sparsely described, as has also the validity of the diagnostic codes. The aim of the study was 1) to clarify whether the aetiology of acute and chronic pancreatitis changed during the period 1983-2005, and 2) to validate the diagnostic codes over time for acute and chronic pancreatitis registered in the Danish National Patient Registry (NPR) in the same period.
All admissions at Hvidovre Hospital coded in the NPR in 1983, 1994 and 2005 with a diagnosis of either acute or chronic pancreatitis were included. After exclusion of readmissions, the cohorts consisted of 92, 146 and 118 patients, respectively. Medical records from every admission were retrieved, the aetiology was assessed and the coding of the diagnoses was related to internationally approved criteria.
Gallstone disease significantly (p = 0.04) increased as the cause of acute pancreatitis over the 22-year period, while alcohol remained the major cause of chronic pancreatitis. The validity of the diagnoses for patients with acute pancreatitis varied between 51% and 73%, and for chronic pancreatitis between 63 and 78%.
急性和慢性胰腺炎的病因随时间的变化鲜有描述，诊断编码的有效性也是如此。本研究的目的是：1）明确1983年至2005年期间急性和慢性胰腺炎的病因是否发生了变化；2）验证同期丹麦国家患者登记处（NPR）登记的急性和慢性胰腺炎诊断编码随时间的有效性。
纳入1983年、1994年和2005年在NPR中编码为诊断为急性或慢性胰腺炎的所有在赫维多夫医院的入院病例。排除再次入院病例后，队列分别由92例、146例和118例患者组成。检索每次入院的病历，评估病因，并将诊断编码与国际认可的标准相关联。
在这22年期间，胆结石疾病作为急性胰腺炎的病因显著增加（p = 0.04），而酒精仍然是慢性胰腺炎的主要病因。急性胰腺炎患者诊断的有效性在51%至73%之间，慢性胰腺炎患者诊断的有效性在63%至78%之间。
