Funai M, Lee J D, Shimizu H, Yamamoto M, Kato T, Shimizu K, Ogawa K, Hara A, Nakamura T
First Department of Internal Medicine, Fukui Medical School.
Kokyu To Junkan. 1991 Feb;39(2):189-92.
A 57-year-old man was admitted to our hospital because he had had attacks of chest pain at rest for more than a year, in spite of daily oral diltiazem (90 mg/day) and isosorbide dinitrate (15 m/day). The diagnosis of variant angina was made for him based on ST elevation in chest leads of the electrocardiogram during his first attack. However, one year later, the electrocardiograms during attacks showed only ST depression or T wave inversion in chest leads. The coronary arteriogram during spontaneous chest pain revealed that the left anterior descending artery was totally occluded at its middle portion, and that its peripheral portion was perfused by collateral circulation from the right coronary artery. The coronary arteriograms after administration of nitroglycerin were apparently normal, and no signs of collateral circulation were observed. These findings indicated that the transient collateral circulation could develop after repetitive coronary artery spasms even in the absence of significant coronary stenosis, and that it could lessen the degree of myocardial ischemia during coronary artery spasm.
一名57岁男性因尽管每日口服地尔硫䓬(90毫克/天)和硝酸异山梨酯(15毫克/天),仍有一年多的静息性胸痛发作而入住我院。根据其首次发作时心电图胸导联ST段抬高,诊断为变异型心绞痛。然而,一年后,发作时的心电图仅显示胸导联ST段压低或T波倒置。自发性胸痛时的冠状动脉造影显示,左前降支动脉在其中段完全闭塞,其外周部分由右冠状动脉的侧支循环供血。给予硝酸甘油后的冠状动脉造影明显正常,未观察到侧支循环的迹象。这些发现表明,即使在没有明显冠状动脉狭窄的情况下,反复冠状动脉痉挛后也可能出现短暂的侧支循环,并且它可以减轻冠状动脉痉挛期间的心肌缺血程度。