Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, 7818 Big Sky Drive, Suite 215, Madison, WI 53719, USA.
Clin Geriatr Med. 2010 Feb;26(1):99-111. doi: 10.1016/j.cger.2009.11.003.
Current knowledge about the roles of cognitively stimulating lifestyles and cognitive training interventions in preserving cognitive function in later life is reviewed. Potential mechanisms for beneficial effects of cognitive stimulation and training are discussed, and key gaps in research identified. Suggestions are provided for advising patients about brain-healthy lifestyles, acknowledging that much remains to be learned in this area of research. More randomized controlled trials, using challenging regimes of training and stimulation and long-term follow-up, are needed, measuring cognitive trajectories in normal aging and relative risk of Alzheimer disease as outcomes.
本文回顾了关于认知刺激生活方式和认知训练干预在保持晚年认知功能方面的作用的现有知识。讨论了认知刺激和训练有益效果的潜在机制，并确定了研究中的关键空白。为向患者提供有关大脑健康生活方式的建议提供了建议，承认在这一研究领域还有很多需要学习的地方。需要更多的随机对照试验，使用具有挑战性的训练和刺激方案以及长期随访，以衡量正常衰老过程中的认知轨迹和阿尔茨海默病的相对风险作为结果。
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