Laboratory of Biomechanics & Biomedical Engineering, Mechanical Engineering & Aeronautics Department, University of Patras, Rion 26504, Greece.
J Biomech. 2010 May 7;43(7):1426-31. doi: 10.1016/j.jbiomech.2010.01.012. Epub 2010 Feb 21.
Endothelial cells (ECs), besides being a permeability barrier between the blood and vessel wall, perform many important functions, e.g., cell migration, remodeling, proliferation, and the production, secretion and metabolism of biochemical substances, as well as the regulation of contractility of vascular smooth muscle cells (SMCs). Their function is modulated by chemical ligands as well as mechanical factors. The mechanical stresses acting on the vessel wall include the normal and circumferential stresses that result from the action of blood pressure, the shear stress that acts parallel to the luminal surface of the vessel due to blood flow and the magnitude and orientation of the gravitation field. The aim of this work was to design and construct a novel bioreactor for the stimulation of endothelial cells in vitro with a combination of mechanical factors that simulates their in vivo environment.
内皮细胞（ECs）不仅是血液和血管壁之间的通透性屏障，还具有许多重要功能，例如细胞迁移、重塑、增殖，以及生化物质的产生、分泌和代谢，以及血管平滑肌细胞（SMCs）的收缩性调节。它们的功能受到化学配体和机械因素的调节。作用于血管壁的机械应力包括由血压作用产生的正常和周向应力、由于血流而作用于血管内腔表面的切变应力以及重力场的大小和方向。本工作的目的是设计和构建一种新型生物反应器，用于体外刺激内皮细胞，同时结合模拟其体内环境的机械因素。
