Jagiellonian University, Faculty of Chemistry, Ingardena 3, 30-060 Kraków, Poland.
Colloids Surf B Biointerfaces. 2010 Jun 1;77(2):298-300. doi: 10.1016/j.colsurfb.2010.01.027. Epub 2010 Feb 4.
Selected fluorinated and hydrogenated surfactants, namely a semifluorinated alkane (SFA): 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-henicosafluorononacosane (F10H19), two long chain alcohols: 18,18,18,17,17,16,16,15,15,14,14,13,13,12,12,11,11-heptadecafluorooctadecane-1-ol (F8H10OH) and octadecane-1-ol (C18OH) and with two long chain thiols of the analogous apolar part structure to the above-mentioned alcohols, i.e.: 18,18,18,17,17,16,16,15,15,14,14,13,13,12,12,11,11-heptadecafluorooctadecane-1-thiol (F8H10SH) and octadecane-1-thiol (C18SH) have been tested in mixtures with valinomycin as potential artificial matrixes for its immobilization. The thermodynamic analysis (DeltaG(exc)vsX(val) plots) based on surface pressure-area isotherm registration for particular valinomycin/surfactant mixtures, complemented with BAM images of the films structure indicate that only fluorinated surfactants are suitable materials for valinomycin incorporation as they form homogeneous miscible monolayers at X(val) below 0.5.
已测试了选定的氟化和氢化表面活性剂，即半氟化烷烃（SFA）：1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-二十氟十一烷（F10H19），两种长链醇：18,18,18,17,17,16,16,15,15,14,14,13,13,12,12,11,11-十七氟十八烷-1-醇（F8H10OH）和十八烷-1-醇（C18OH），以及与上述醇具有类似非极性部分结构的两种长链硫醇，即：18,18,18,17,17,16,16,15,15,14,14,13,13,12,12,11,11-十七氟十八烷-1-硫醇（F8H10SH）和十八烷-1-硫醇（C18SH），已在与缬氨霉素混合的情况下进行了测试，作为其固定化的潜在人工基质。基于表面压-面积等温线注册的热力学分析（DeltaG(exc)vsX(val) 图），以及薄膜结构的 BAM 图像，表明只有氟化表面活性剂才是适合的缬氨霉素掺入材料，因为它们在 X(val)低于 0.5 时形成均匀的可混溶单层。
