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[果蝇发育中Pax基因家族的调控功能]

[Regulatory functions of Pax gene family in Drosophila development].

作者信息

Li Li, Yang Yang, Xue Lei

机构信息

School of Life Science and Technology, Tongji University, Shanghai 200092, China.

出版信息

Yi Chuan. 2010 Feb;32(2):115-21. doi: 10.3724/sp.j.1005.2010.00115.

Abstract

The Pax gene family encodes a group of important transcription factors that have been evolutionary conserved from Drosophila to human. Pax genes play pivotal roles in regulating diverse signal transduction pathways and organogenesis during embryonic development through modulating cell proliferation and self-renewal, embryonic precursor cell migration, and the coordination of specific differentiation programs. Ten members of the Pax gene family, which perform crucial regulatory functions during embryonic and postembryonic development, have been identified in Drosophila. In this report, we described the protein structures, expression patterns, and main functions of Drosophila Pax genes.

摘要

Pax基因家族编码一组重要的转录因子,从果蝇到人类,它们在进化过程中一直保持保守。Pax基因在胚胎发育过程中通过调节细胞增殖和自我更新、胚胎前体细胞迁移以及特定分化程序的协调,在调控多种信号转导途径和器官发生中发挥关键作用。在果蝇中已鉴定出Pax基因家族的十个成员,它们在胚胎期和胚后期发育过程中发挥着至关重要的调节功能。在本报告中,我们描述了果蝇Pax基因的蛋白质结构、表达模式和主要功能。

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