Ding Yan-Fei, Wang Guang-Yue, Fu Ya-Ping, Zhu Cheng
College of Life Sciences, Zhejiang University, Hangzhou 310029, China.
Yi Chuan. 2010 Feb;32(2):129-34. doi: 10.3724/sp.j.1005.2010.00129.
MicroRNAs (miRNAs) are a new class of small RNAs, which act as post-transcriptional negative regulators of gene expression. Plant miRNAs are important in the regulation of plant growth, development and in response to various abiotic and biotic stresses. miR398 is the first reported miRNA to be down-regulated by oxidative stresses. miR398 plays an impor-tant role in stresses, such as regulating copper homeostasis, in response to abiotic stresses including heavy metals, sucrose, and ozone and biotic stresses via down-regulating the expression of Cu/Zn-superoxide dismutase (CSD). This review fo-cused on the crucial role of miR398 in regulation of different stresses and the transcriptional regulation of MIR398 gene.
微小RNA(miRNA)是一类新型小RNA,作为基因表达的转录后负调控因子发挥作用。植物miRNA在植物生长、发育以及应对各种非生物和生物胁迫的调控中具有重要作用。miR398是首个被报道受氧化胁迫下调的miRNA。miR398在胁迫中发挥重要作用,例如通过下调铜/锌超氧化物歧化酶(CSD)的表达来调节铜稳态,以应对包括重金属、蔗糖、臭氧等非生物胁迫以及生物胁迫。本综述聚焦于miR398在不同胁迫调控中的关键作用以及MIR398基因的转录调控。