Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China.
Physiol Plant. 2011 Sep;143(1):1-9. doi: 10.1111/j.1399-3054.2011.01477.x. Epub 2011 May 19.
Because of their sessile nature, plants are constantly exposed to a multitude of abiotic and biotic stresses. Great progress has been made in elucidating the complex stress response mechanisms in plants. MicroRNAs (miRNAs), recently recognized as important regulators of gene expression at the posttranscriptional level, have been found to be involved in plant stress responses. Most plant miRNAs usually mediate cleavage of their target mRNAs. The observation that some miRNAs are up- or downregulated in response to stress implies that miRNAs play vital roles in plant resistance to abiotic and biotic stresses. Manipulation of miRNA-guided gene regulation may represent a new way to engineer plants with improved stress tolerance. Among stress-responsive miRNAs, miRNA398 (miR398) is a miRNA proposed to be directly linked to the plant stress regulatory network and regulates plant responses to oxidative stress, water deficit, salt stress, abscisic acid stress, ultraviolet stress, copper and phosphate deficiency, high sucrose and bacterial infection. This review highlights recent progress in understanding the crucial role of miR398 in plant stress responses, and also includes a discussion of miR398-centered gene regulatory network.
由于其固着的性质，植物不断暴露于多种非生物和生物胁迫下。在阐明植物复杂的应激反应机制方面已经取得了巨大进展。微小 RNA（miRNA），最近被认为是在转录后水平上调控基因表达的重要调控因子，被发现参与了植物的应激反应。大多数植物 miRNA 通常介导其靶 mRNA 的切割。一些 miRNA 对胁迫的响应呈上调或下调的观察结果表明，miRNA 在植物对非生物和生物胁迫的抗性中起着至关重要的作用。miRNA 指导的基因调控的操纵可能代表了一种新的方法，可以设计出对胁迫具有更高耐受性的植物。在应激响应 miRNA 中，miR398（miR398）是一种被认为与植物应激调控网络直接相关的 miRNA，调节植物对氧化应激、水分亏缺、盐胁迫、脱落酸胁迫、紫外线胁迫、铜和磷酸盐缺乏、高蔗糖和细菌感染的反应。本文综述了近年来对 miR398 在植物应激反应中的关键作用的理解进展，并讨论了以 miR398 为中心的基因调控网络。
