Nearing B D, Huang A H, Verrier R L
Georgetown University School of Medicine, Washington, DC 20007.
Science. 1991 Apr 19;252(5004):437-40. doi: 10.1126/science.2017682.
A link is found between T wave alternans and vulnerability to ventricular fibrillation, and a new approach is provided for quantification of susceptibility to malignant arrhythmias. Complex demodulation reveals that alternation of the electrocardiogram is concentrated during the first half of the T wave, coinciding with the vulnerable period of the cardiac cycle. During myocardial ischemia and reperfusion, there are marked increases in the degree of T wave alternans that parallel the established time course of changes in vulnerability. The influence of the sympathetic nervous system in arrhythmogenesis is also accurately detected. Ultimately, complex demodulation of the electrocardiogram could provide a technique for identification and management of individuals at risk for sudden cardiac death.
发现T波交替与心室颤动易感性之间存在联系，并为量化恶性心律失常的易感性提供了一种新方法。复解调显示心电图的交替集中在T波的前半段，与心动周期的易损期一致。在心肌缺血和再灌注期间，T波交替程度显著增加，与已确定的易损性变化时间进程平行。交感神经系统在心律失常发生中的影响也能被准确检测到。最终，心电图的复解调可为识别和管理有心脏性猝死风险的个体提供一种技术。
