N-苄基-D-葡糖胺二硫代氨基甲酸盐对顺二氯二氨铂诱导的大鼠肾毒性的防护作用。

Protection against cis-diamminedichloroplatinum-induced nephrotoxicity in rats by N-benzyl-D-glucamine dithiocarbamate.

作者信息

Kiyozumi M, Inoue T, Kojima S, Hidaka S, Tsuruoka M

机构信息

Department of School Health, Faculty of Education, Kumamoto University, Japan.

出版信息

Toxicology. 1991 Mar 25;67(1):41-51. doi: 10.1016/0300-483x(91)90162-t.

DOI:10.1016/0300-483x(91)90162-t

PMID:2017764

Abstract

Sodium N-benzyl-D-glucamine dithiocarbamate (BGD) was evaluated for its efficacy as an inhibitor of cis-diamminedichloroplatinum (DDP)-induced nephrotoxicity in a rat model. Treatment with 2.0 mmol/kg of BGD immediately after DDP injection effectively prevented nephrotoxic effects of DDP, but administration of BGD -1 or 1 h after DDP afforded a small protection. Concurrent treatment with 0.5 mmol/kg of BGD could not prevent renal damage. The platinum concentrations in liver and kidney were significantly decreased by BGD treatment. The antitumor efficacy of DDP in the Walker 256 carcinoma-bearing rats was not affected by administration of BGD (2.0 mmol/kg).

摘要

在大鼠模型中评估了N-苄基-D-葡糖胺二硫代氨基甲酸钠（BGD）作为顺二氯二氨铂（DDP）诱导的肾毒性抑制剂的功效。在注射DDP后立即用2.0 mmol/kg的BGD进行治疗可有效预防DDP的肾毒性作用，但在DDP注射后-1或1小时给予BGD则提供了较小的保护作用。同时用0.5 mmol/kg的BGD进行治疗不能预防肾损伤。BGD治疗可使肝脏和肾脏中的铂浓度显著降低。给予BGD（2.0 mmol/kg）不会影响DDP对携带Walker 256癌的大鼠的抗肿瘤功效。