兔子的胶原蛋白毒性
Collagen toxicity in rabbits.
作者信息
Gomes S A, Thomson M, Ali M, Alnaqeeb M, Khater S H
机构信息
Department of Biochemistry, Faculty of Science, Kuwait University, Safat.
出版信息
Toxicol Lett. 1991 Apr;56(1-2):229-35. doi: 10.1016/0378-4274(91)90110-r.
Different preparations of soluble collagen, from rabbit skin, rat skin, rat tail tendon and guinea-pig skin, produced respiratory distress, agitation, convulsions and finally death when infused intravenously in lethal doses. Analysis of plasma enzyme levels indicated significant increases in total, cardiac and hepatic lactate dehydrogenase, suggesting that damage to the liver occurred as a result of collagen infusion. Histopathological examination of lungs, livers and hearts of collagen-treated rabbits confirmed that damage had occurred to the lungs and livers of these animals, while heart tissues appeared to be normal. The source of collagen did not appear to influence its toxicity at the tissue level.
来自兔皮、大鼠皮肤、大鼠尾腱和豚鼠皮肤的不同可溶性胶原蛋白制剂，当静脉注射致死剂量时，会产生呼吸窘迫、躁动、惊厥，最终导致死亡。血浆酶水平分析表明，总乳酸脱氢酶、心肌乳酸脱氢酶和肝乳酸脱氢酶显著升高，提示胶原蛋白输注导致肝脏损伤。对经胶原蛋白处理的兔子的肺、肝和心脏进行组织病理学检查证实，这些动物的肺和肝发生了损伤，而心脏组织似乎正常。胶原蛋白的来源似乎不影响其在组织水平的毒性。
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