大蒜对兔子胶原蛋白和花生四烯酸毒性保护作用的组织病理学证据。

Histopathological evidence of protective action of garlic against collagen and arachidonic acid toxicity in rabbits.

作者信息

Alnaqeeb M A, Ali M, Thomson M, Khater S H, Gomes S A, al-Hassan J M

机构信息

Department of Zoology, Faculty of Science, Kuwait University, Safat.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1992 Aug;46(4):301-6. doi: 10.1016/0952-3278(92)90040-p.

DOI:10.1016/0952-3278(92)90040-p

PMID:1409768

Abstract

Soluble rat tail tendon collagen produced respiratory distress, agitation, convulsions and finally death in rabbits when infused intravenously (i.v.) in lethal doses. Similar observations were noted when a lethal dose of arachidonic acid (unsaturated essential fatty acid) was infused. These agents caused thrombocytopenia, indicative of in vivo platelet aggregation, hypotension and increased levels of thromboxane (TX) B2 (a stable metabolite of TXA2) in the plasma. Histopathological examination of lung, heart and liver tissue indicated that the lungs and livers of treated animals were adversely affected, while heart tissues appeared to be normal. Histopathological examination of lung and liver tissues of animals pretreated with garlic, then treated with a lethal dose of collagen or arachidonic acid showed a significant reduction in the damage observed compared to animals not pretreated with garlic.

摘要

静脉注射（i.v.）致死剂量的可溶性大鼠尾腱胶原蛋白会使兔子产生呼吸窘迫、躁动、抽搐，最终死亡。当注入致死剂量的花生四烯酸（不饱和必需脂肪酸）时，也观察到了类似的情况。这些物质导致血小板减少，表明体内血小板聚集，还导致低血压以及血浆中血栓素（TX）B2（TXA2的稳定代谢产物）水平升高。对肺、心脏和肝脏组织的组织病理学检查表明，接受治疗的动物的肺和肝脏受到了不利影响，而心脏组织似乎正常。对先用大蒜预处理，然后用致死剂量的胶原蛋白或花生四烯酸处理的动物的肺和肝脏组织进行组织病理学检查，结果显示，与未用大蒜预处理的动物相比，观察到的损伤明显减少。