豚鼠体内甲基异丁基酮（MIBK）的经皮吸收及动力学

Percutaneous uptake and kinetics of methyl isobutyl ketone (MIBK) in the guinea-pig.

作者信息

Hjelm E W, Boman A, Fernström P, Hagberg M, Johanson G

机构信息

Division of Work and Environmental Physiology, National Institute of Occupational Health, Solna, Sweden.

出版信息

Toxicol Lett. 1991 Apr;56(1-2):79-86. doi: 10.1016/0378-4274(91)90092-k.

DOI:10.1016/0378-4274(91)90092-k

PMID:2017787

Abstract

Continuous intravenous infusion of 0.478 mumol/min methyl isobutyl ketone (MIBK) was performed for 30 min in pentobarbital-anesthetized guinea-pigs. Epicutaneous exposure for 150 min was carried out 2.5 h later after administration of MIBK to a sealed glass ring on the clipped back of the animals. Arterial blood was analyzed for MIBK by gas chromatography. Blood clearance averaged 201 ml.min-1.kg-1 body wt. A maximum percutaneous uptake of 1.1 mumol.min-1.cm-2 was reached 10-45 min after the onset of exposure and decreased to 0.56 mumol.min-1.cm-2 during the latter part of exposure.

摘要

在戊巴比妥麻醉的豚鼠中持续静脉输注0.478微摩尔/分钟的甲基异丁基酮（MIBK），持续30分钟。在给予MIBK 2.5小时后，将一个密封的玻璃环放置在动物背部剪毛处，进行150分钟的经皮暴露。通过气相色谱法分析动脉血中的MIBK。血液清除率平均为201毫升·分钟⁻¹·千克⁻¹体重。暴露开始后10 - 45分钟达到最大经皮摄取量1.1微摩尔·分钟⁻¹·平方厘米，在暴露后期降至0.56微摩尔·分钟⁻¹·平方厘米。