Díaz Barriga-Arceo S, Madrigal-Bujaidar E
Departamento de Morfología, Escuela Nacional de Ciencias Biológicas, Mexico, D.F.
Toxicol Lett. 1991 Apr;56(1-2):95-8. doi: 10.1016/0378-4274(91)90094-m.
Letimide, 3[2-(diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione, a new analgesic, is a cyclic derivative of a salicylamide with a higher pharmacological potency than acetylsalicylic acid. In this study we evaluated its clastogenic activity using the micronucleus test in vivo. Our results did not show any clastogenic effect produced by letimide as compared with control mice and animals treated with cyclophosphamide.
来替米德，即3-[2-(二乙氨基)乙基]-2H-1,3-苯并恶嗪-2,4(3H)-二酮，一种新型镇痛药，是水杨酰胺的环状衍生物，其药理活性比乙酰水杨酸更高。在本研究中，我们通过体内微核试验评估了其致断裂活性。与对照小鼠和用环磷酰胺处理的动物相比，我们的结果未显示来替米德产生任何致断裂效应。
