Divisione di Ematologia, Ospedali Riuniti, Largo Barozzi 1, 24100 Bergamo, Italy.
Int J Hematol. 2010 Mar;91(2):180-8. doi: 10.1007/s12185-010-0532-x. Epub 2010 Feb 24.
Myelofibrosis shows a progressive clinical course and usually a poor, lethal prognosis. Allogeneic transplantation is an effective, potentially curable treatment approach although only a minority of patients may currently benefit from it. New effective treatment strategies are becoming available for this disease, including not only JAK2 inhibitors, but also other innovative drugs, targeting more general oncogenic mechanisms and the epigenetic control of cell proliferation and differentiation.
骨髓纤维化表现为进行性临床病程，通常预后不良且致命。异基因移植是一种有效且可能治愈的治疗方法，但目前只有少数患者可能从中受益。针对这种疾病，新的有效治疗策略正在出现，不仅包括 JAK2 抑制剂，还包括其他针对更普遍致癌机制以及细胞增殖和分化的表观遗传控制的创新药物。
