fMRI tracks reductions in repetitive behaviors in autism: two case studies.
作者信息
Dichter Gabriel S, Sikich Linmarie, Mahorney Steve, Felder Jennifer N, Lam Kristen S L, Turner-Brown Lauren, Bodfish James
机构信息
Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-3366, USA.
出版信息
Neurocase. 2010 Aug;16(4):307-16. doi: 10.1080/13554790903559671. Epub 2010 Feb 22.
Abstract
Autism is characterized by abnormal prefrontal brain activation during cognitive control, a potential biomarker of repetitive behaviors. In this proof-of-principle study, functional magnetic resonance imaging (fMRI) was used to examine brain activity during an oddball task in two high-functioning males with autism before and after 12 weeks of treatment with citalopram, a selective serotonin reuptake inhibitor. One participant showed marked reductions in repetitive behaviors whereas the other showed mild worsening. Brain activation in relevant prefrontal regions increased in only the participant whose repetitive behavior symptoms improved. These findings suggest that fMRI may elucidate potential mechanisms of action of targeted autism interventions.
摘要
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1
Autism is characterized by dorsal anterior cingulate hyperactivation during social target detection.
Soc Cogn Affect Neurosci. 2009 Sep;4(3):215-26. doi: 10.1093/scan/nsp017. Epub 2009 Jul 2.
2
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Arch Gen Psychiatry. 2009 Jun;66(6):583-90. doi: 10.1001/archgenpsychiatry.2009.30.
3
Changes in the developmental trajectories of striatum in autism.
Biol Psychiatry. 2009 Aug 15;66(4):327-33. doi: 10.1016/j.biopsych.2009.03.017. Epub 2009 May 7.
4
Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder.
Am J Psychiatry. 2009 Jan;166(1):64-73. doi: 10.1176/appi.ajp.2008.07081336. Epub 2008 Dec 1.
5
Brain hyper-reactivity to auditory novel targets in children with high-functioning autism.
Brain. 2008 Sep;131(Pt 9):2479-88. doi: 10.1093/brain/awn172. Epub 2008 Jul 31.
6
Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD).
Brain. 2008 Sep;131(Pt 9):2464-78. doi: 10.1093/brain/awn099. Epub 2008 Jun 11.
7
Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder.
Brain. 2008 Jan;131(Pt 1):155-64. doi: 10.1093/brain/awm277. Epub 2007 Dec 7.
8
The neural circuitry mediating shifts in behavioral response and cognitive set in autism.
Biol Psychiatry. 2008 May 15;63(10):974-80. doi: 10.1016/j.biopsych.2007.06.028. Epub 2007 Oct 4.
9
A developmental fMRI study of self-regulatory control in Tourette's syndrome.
Am J Psychiatry. 2007 Jun;164(6):955-66. doi: 10.1176/ajp.2007.164.6.955.
10
The Repetitive Behavior Scale-Revised: independent validation in individuals with autism spectrum disorders.
J Autism Dev Disord. 2007 May;37(5):855-66. doi: 10.1007/s10803-006-0213-z.
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