Xiong Ye, Mahmood Asim, Chopp Michael
Henry Ford Health System, Department of Neurology, E&R Building, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Curr Opin Investig Drugs. 2010 Mar;11(3):298-308.
Stroke and traumatic brain injury (TBI) are major causes of mortality and morbidity worldwide. Unfortunately, almost all phase III clinical trials of neuroprotective agents for stroke and TBI have demonstrated no benefit, raising concerns regarding the use of neuroprotective strategies alone as therapy for acute brain injuries. Therefore, a compelling need exists to develop treatments that promote both the repair and regeneration of injured brain tissue, and functional recovery. Recent data suggest that strategies to enhance neurogenesis and angiogenesis following brain injuries may provide promising opportunities to improve clinical outcomes and brain functional recovery. This review discusses neurogenesis and angiogenesis in the adult brain following stroke or TBI. Selected cell-based and pharmacological therapies are highlighted that promote neurogenesis and angiogenesis and are designed to restore neurological function after brain injuries. These discoveries emphasize the need for an improved understanding of injury- and therapy-induced neurogenesis and angiogenesis in the adult brain, and suggest that the manipulation of endogenous neural precursors and endothelial cells is a potential therapy for brain injury.
中风和创伤性脑损伤（TBI）是全球范围内导致死亡和发病的主要原因。不幸的是，几乎所有用于中风和TBI的神经保护剂的III期临床试验都没有显示出益处，这引发了对仅使用神经保护策略作为急性脑损伤治疗方法的担忧。因此，迫切需要开发能够促进受损脑组织修复和再生以及功能恢复的治疗方法。最近的数据表明，脑损伤后增强神经发生和血管生成的策略可能为改善临床结果和脑功能恢复提供有希望的机会。本综述讨论了中风或TBI后成人大脑中的神经发生和血管生成。重点介绍了选定的基于细胞和药物的疗法，这些疗法可促进神经发生和血管生成，并旨在恢复脑损伤后的神经功能。这些发现强调了需要更好地理解成人大脑中损伤和治疗诱导的神经发生和血管生成，并表明对内源性神经前体细胞和内皮细胞的操纵是一种潜在的脑损伤治疗方法。
