Miljan Erik A, Sinden John D
ReNeuron Group plc, Surrey Research Park, Surrey, UK.
Curr Opin Mol Ther. 2009 Aug;11(4):394-403.
The development of a neural stem cell (NSC) treatment for ischemic brain injury would be of great benefit. This review focuses on recent advances in knowledge and practices toward the development of a successful NSC therapy for patients who have experienced stroke. The data supporting potential mechanisms by which somatic stem cells orchestrate neuroprotection, neurogenesis and vascularization, leading to pronounced functional improvements in stroke-induced deficits are critically reviewed. A model is proposed in which the host's immune system plays a central role in stem cell-induced neural repair. In addition, the source of stem cells and the effect of immunosuppression in clinical trials of stem cell therapy are discussed. The beneficial effects of NSCs in animal models of stroke, combined with a consideration of clinical requirements, can potentially provide an effective NSC treatment for patients who have experienced stroke.
开发用于缺血性脑损伤的神经干细胞（NSC）治疗将大有裨益。本综述聚焦于针对中风患者开发成功的NSC疗法在知识和实践方面的最新进展。对支持体细胞干细胞协调神经保护、神经发生和血管生成从而显著改善中风所致功能缺损的潜在机制的数据进行了严格审查。提出了一个模型，其中宿主免疫系统在干细胞诱导的神经修复中起核心作用。此外，还讨论了干细胞来源以及免疫抑制在干细胞治疗临床试验中的作用。NSC在中风动物模型中的有益作用，结合对临床需求的考虑，有可能为中风患者提供有效的NSC治疗。
