Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
Org Lett. 2010 Mar 19;12(6):1280-3. doi: 10.1021/ol100169r.
Asymmetric cyanation of a class of easily available olefins with a favorable cyanide source ethyl cyanoformate (CNCOOEt) was realized by an interesting modular catalyst. High yields and ee values were obtained for a range of substrates under solvent-free and mild reaction conditions. The products obtained could be easily transformed to the enantioenriched useful intermediates 5, 6, and pharmaceutically important gamma-aminobutyric acid 7.
一类易得的烯烃与有利的氰源氰基甲酸乙酯（CNCOOEt）通过一种有趣的模块化催化剂实现了不对称氰化。在无溶剂和温和的反应条件下，一系列底物都能获得高产率和高对映选择性。得到的产物可以很容易地转化为手性富集的有用中间体 5、6 和具有重要药用价值的γ-氨基丁酸 7。
