容积调节型氯离子通道与脑血管重塑。

Volume-regulated chloride channels and cerebral vascular remodelling.

机构信息

Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.

出版信息

Clin Exp Pharmacol Physiol. 2010 Feb;37(2):238-42. doi: 10.1111/j.1440-1681.2008.05137.x.

DOI:10.1111/j.1440-1681.2008.05137.x

Abstract

Transmembrane Cl(-) transport through volume-regulated Cl(-) channels (VRCC) is implicated in cell cycle control and the proliferation of vascular smooth muscle cells (VSMC). In cerebrovascular VSMC, volume-regulated Cl(-) movement is enhanced with the severity of cerebrovascular remodelling induced by hypertension. 2. Expression of the ClC-3 chloride channel, a potential molecular candidate for the VRCC, is significantly increased with the progression of VSMC proliferation, but is decreased in apoptosis. 3. In the present review, we summarize recent findings regarding the functional role of volume-regulated ClC-3 chloride channels in VSMC proliferation, apoptosis and cerebrovascular remodelling during the development of hypertension. In addition, we discuss the relationship between the channel and intracellular signalling pathways, including the production of reactive oxygen species and the phosphorylation of Akt. 4. Recent studies strongly suggest that VRCC/ClC-3 is involved in the regulation of both cell proliferation and apoptosis. These findings suggest that ClC-3 chloride channels may be potential new targets for the prevention of the cerebrovascular remodelling that occurs during the development of hypertension.

摘要

通过体积调节氯离子通道（VRCC）的跨膜 Cl(-) 转运与细胞周期控制和血管平滑肌细胞（VSMC）的增殖有关。在脑血管平滑肌细胞中，随着高血压引起的脑血管重塑的严重程度的增加，体积调节 Cl(-) 运动增强。
氯离子通道 ClC-3 的表达，作为 VRCC 的潜在分子候选物，随着 VSMC 增殖的进展而显著增加，但在细胞凋亡中减少。
在本综述中，我们总结了关于体积调节 ClC-3 氯离子通道在高血压发展过程中血管平滑肌细胞增殖、凋亡和脑血管重塑中的功能作用的最新发现。此外，我们还讨论了该通道与包括活性氧产生和 Akt 磷酸化在内的细胞内信号通路之间的关系。
最近的研究强烈表明，VRCC/ClC-3 参与了细胞增殖和凋亡的调节。这些发现表明，ClC-3 氯离子通道可能是预防高血压发展过程中发生的脑血管重塑的潜在新靶点。