Schneider S M, Vanscoy G, Michelson E A
Department of Medicine, Montefiore Hospital, University of Pittsburgh, PA 15213.
Vet Hum Toxicol. 1991 Feb;33(1):17-8.
Phalloidin, a toxin of the mushroom Amanita phalloides, was felt to act as a pro-toxin, converted by hepatic microsomal mixed function oxidase enzymes. Therefore, pretreatment with cimetidine, a potent P450 cytochrome system inhibitor, might be expected to prevent the toxic conversion. In our mouse animal model of phalloidin exposure, pretreatment with 120 mg cimetidine/kg ip failed to improve survival compared to placebo pretreatment. Moreover, cimetidine pretreatment decreased survival (p less than 0.03). These results support an alternate mechanism for phalloidin toxicity, ie, that the toxic effects are related to the interaction of phalloidin with F-actin.
鬼笔环肽是一种毒蝇伞蘑菇的毒素，被认为是一种前毒素，可由肝脏微粒体混合功能氧化酶转化。因此，西咪替丁（一种强效的P450细胞色素系统抑制剂）预处理有望防止毒性转化。在我们的鬼笔环肽暴露小鼠动物模型中，与安慰剂预处理相比，120mg西咪替丁/千克腹腔注射预处理未能提高生存率。此外，西咪替丁预处理降低了生存率（p小于0.03）。这些结果支持了鬼笔环肽毒性的另一种机制，即毒性作用与鬼笔环肽与F-肌动蛋白的相互作用有关。
