Mahadevan Padmanabhan, Seto Donald
Department of Bioinformatics and Computational Biology, 10900 University Blvd,, MSN 5B3, George Mason University, Manassas, VA 20110, USA.
BMC Res Notes. 2010 Feb 23;3:41. doi: 10.1186/1756-0500-3-41.
The growing whole genome sequence databases necessitate the development of user-friendly software tools to mine these data. Web-based tools are particularly useful to wet-bench biologists as they enable platform-independent analysis of sequence data, without having to perform complex programming tasks and software compiling.
GeneOrder4.0 is a web-based "on-the-fly" synteny and gene order analysis tool for comparative bacterial genomics (ca. 8 Mb). It enables the visualization of synteny by plotting protein similarity scores between two genomes and it also provides visual annotation of "hypothetical" proteins from older archived genomes based on more recent annotations.
The web-based software tool GeneOrder4.0 is a user-friendly application that has been updated to allow the rapid analysis of synteny and gene order in large bacterial genomes. It is developed with the wet-bench researcher in mind.
不断增长的全基因组序列数据库需要开发用户友好的软件工具来挖掘这些数据。基于网络的工具对实验台生物学家特别有用，因为它们能够对序列数据进行独立于平台的分析，而无需执行复杂的编程任务和软件编译。
GeneOrder4.0是一个基于网络的“即时”共线性和基因顺序分析工具，用于比较细菌基因组学（约8兆字节）。它通过绘制两个基因组之间的蛋白质相似性得分来实现共线性的可视化，并且还基于更新的注释对来自旧存档基因组的“假设”蛋白质进行可视化注释。
基于网络的软件工具GeneOrder4.0是一个用户友好的应用程序，已更新以允许对大型细菌基因组中的共线性和基因顺序进行快速分析。它是在考虑实验台研究人员的情况下开发的。
