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控制 H(2)O(2)以实现安全信号转导。

Reining in H(2)O(2) for safe signaling.

机构信息

DSV, IBITECS, Laboratoire Stress Oxydants et Cancer, CEA-Saclay, Gif-sur-Yvette, France.

出版信息

Cell. 2010 Feb 19;140(4):454-6. doi: 10.1016/j.cell.2010.02.003.

DOI:10.1016/j.cell.2010.02.003
PMID:20178737
Abstract

Mammalian cells use hydrogen peroxide (H(2)O(2)) not only to kill invading pathogens, but also as a signaling modulator. Woo et al. (2010) now show that the local inactivation of a H(2)O(2)-degrading enzyme ensures that the production of this oxidant is restricted to the signaling site.

摘要

哺乳动物细胞不仅利用过氧化氢 (H(2)O(2)) 来杀死入侵的病原体，还将其作为一种信号调节剂。Woo 等人（2010 年）现在表明，局部失活一种 H(2)O(2) 降解酶可确保这种氧化剂的产生仅限于信号部位。

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