DNA 修复：MutM 如何在干草堆中找到针。
DNA repair: how MutM finds the needle in a haystack.
机构信息
Institute of Molecular Cancer Research, University of Zurich and ETH Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
出版信息
Curr Biol. 2010 Feb 23;20(4):R145-7. doi: 10.1016/j.cub.2009.12.046.
PMID:20178755
Abstract
High-resolution crystal structures of DNA complexes with the bacterial MutM protein show how the enzyme feels its way around the double helix in search of an oxidized guanine before flipping it out into its active site and excising it.
摘要
高分辨率的 DNA 与细菌 MutM 蛋白复合物晶体结构显示了该酶在双螺旋中寻找氧化鸟嘌呤的方式，然后将其翻转到活性位点并切除。
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