Department of Physiology & Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, United States.
Steroids. 2010 Nov;75(11):766-71. doi: 10.1016/j.steroids.2010.02.010. Epub 2010 Feb 21.
SLE is a chronic autoimmune inflammatory disorder that predominantly affects young women. Based on this observation, it has been speculated that sex steroids, particularly estrogens, contribute to SLE disease progression. Young women with SLE are at an increased risk for the development of hypertension yet the reasons for this are unclear. One potential mechanism for the increased risk of hypertension during SLE is the chronic inflammation caused by immune complex mediated tissue injury. Estrogens are known to have an immunomodulatory role that can lead to the production of characteristic autoantibodies important for immune complex formation. Therefore, it is conceivable that during SLE estrogens contribute to tissue injury, increased inflammation and hypertension. This brief review discusses the increased risk for hypertension during SLE, the role of estrogens in immune system function, evidence for estrogens in SLE, and a possible link between estrogens and SLE hypertension.
SLE 是一种慢性自身免疫性炎症性疾病，主要影响年轻女性。基于这一观察结果，人们推测性激素，特别是雌激素，有助于 SLE 疾病的进展。患有 SLE 的年轻女性发生高血压的风险增加，但原因尚不清楚。SLE 期间高血压风险增加的一个潜在机制是免疫复合物介导的组织损伤引起的慢性炎症。雌激素具有免疫调节作用，可导致形成特征性自身抗体，这对免疫复合物的形成很重要。因此，可以想象，在 SLE 期间，雌激素会导致组织损伤、炎症增加和高血压。这篇简短的综述讨论了 SLE 期间高血压风险增加、雌激素在免疫系统功能中的作用、SLE 中雌激素的证据，以及雌激素与 SLE 高血压之间的可能联系。
