D'Alessandro R, Granieri E, Benassi G, Tola M R, Casmiro M, Mazzanti B, Gamberini G, Caniatti L
Institute of Neurology, University of Bologna, Italy.
Acta Neurol Scand. 1991 Feb;83(2):83-8. doi: 10.1111/j.1600-0404.1991.tb04654.x.
This cooperative study was performed in the provinces of Bologna and Ferrara to estimate the prevalence rate of Myasthenia Gravis (MG). Two independent groups used the same case collection method and diagnostic criteria. The study was performed from January 1, 1987 to March 1, 1988. Cases were collected through: 1) review of clinical files from neurology clinics in Bologna and Ferrara, and from the main North-Italian centers for MG (neurology clinics of Milan and Turin; thoracic surgery unit, Turin); 2) thoracic surgery and intensive care units in Bologna and Ferrara; 3) physicians prescribing anticholinesterase drugs. Prevalence rates of generalized MG per million population were 60.9 in the city and 41.0 in the remaining province for Bologna and 118.9 in the city and 87.9 in the remaining province for Ferrara. The difference in prevalence rates between the two areas was statistically significant. Our survey shows that prevalence studies on MG may be biased by factors that cannot be controlled and that most previous studies have probably underestimated the prevalence of MG.
这项合作研究在博洛尼亚省和费拉拉省开展，旨在估算重症肌无力（MG）的患病率。两个独立小组采用相同的病例收集方法和诊断标准。研究从1987年1月1日至1988年3月1日进行。病例通过以下方式收集：1）查阅博洛尼亚和费拉拉神经病学诊所以及意大利北部主要的MG治疗中心（米兰和都灵的神经病学诊所；都灵胸外科）的临床档案；2）博洛尼亚和费拉拉的胸外科及重症监护病房；3）开具抗胆碱酯酶药物的医生。博洛尼亚市每百万人口中全身型MG的患病率为60.9，该省其他地区为41.0；费拉拉市每百万人口中全身型MG的患病率为118.9，该省其他地区为87.9。两个地区患病率的差异具有统计学意义。我们的调查表明，MG患病率研究可能会受到无法控制的因素的影响而产生偏差，并且大多数先前的研究可能低估了MG的患病率。
