Kenny D, Wynsen J C, Brooks H L, Warltier D C
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226.
Am Heart J. 1991 May;121(5):1339-47. doi: 10.1016/0002-8703(91)90136-6.
The effects of dipyridamole (20 and 40 micrograms/kg/min intravenously) on the time course of functional recovery of myocardium after five 5-minute coronary artery occlusions and four 5-minute reperfusions and a subsequent 5-hour reperfusion period were studied in chronically instrumented, conscious dogs with well-developed coronary collateral circulation. In comparison with vehicle-treated control dogs, those given dipyridamole (20 and 40 micrograms/kg/min, respectively) 15 minutes before and during coronary occlusion had a greater depression of regional segment shortening (38 +/- 7% and 19 +/- 4%, respectively, vs control levels of 69 +/- 10% of preocclusion values) during acute coronary artery occlusion. After a 5-hour reperfusion period, segment shortening returned to preocclusion values in the control group but remained decreased in the dipyridamole groups (87 +/- 4% and 75%, respectively). These results suggest that dipyridamole in a dose-dependent manner exacerbates recovery of contractility of postischemic reperfused myocardium in dogs with well-developed coronary collateral circulation.
在具有良好冠状动脉侧支循环的慢性植入仪器的清醒犬中，研究了双嘧达莫（静脉注射剂量为20和40微克/千克/分钟）对五次5分钟冠状动脉闭塞、四次5分钟再灌注以及随后5小时再灌注期后心肌功能恢复时间进程的影响。与赋形剂处理的对照犬相比，在冠状动脉闭塞前15分钟及闭塞期间给予双嘧达莫（分别为20和40微克/千克/分钟）的犬，在急性冠状动脉闭塞期间区域节段缩短程度更大（分别为38±7%和19±4%，而对照水平为闭塞前值的69±10%）。在5小时再灌注期后，对照组的节段缩短恢复到闭塞前值，但双嘧达莫组仍降低（分别为87±4%和75%）。这些结果表明，在具有良好冠状动脉侧支循环的犬中，双嘧达莫以剂量依赖的方式加剧了缺血后再灌注心肌收缩力的恢复。
