Department of Clinical Pain, Xuanwu Hospital, Capital Medical University, 45 Changchun St, Xuanwu District, Beijing, People's Republic of China.
Eur Radiol. 2010 Jun;20(6):1424-30. doi: 10.1007/s00330-009-1693-y. Epub 2010 Feb 24.
To investigate the value of computed tomography (CT) perfusion imaging for assessment of angiogenesis in liver cancer.
Twenty-one patients with histologically proven liver cancer underwent CT perfusion examination. We compared the following perfusion parameters in the tumour area versus the non-tumour area: total blood flow (TBF), hepatic arterial perfusion (HAP), hepatic portal perfusion (HPP) and hepatic arterial perfusion index (HAPI). Slices of postoperative specimen were stained with haematoxylin-eosin and anti-CD34 immunohistochemistry. The slices were evaluated with emphasis on the CD34-positive neovasculature in the tumour parenchyma. Tumour microvascular density (MVD) was calculated according to the Weidner method. Pearson correlation was used to detect correlations between tumour MVD and tumour perfusion parameters.
TBF and HPP in the tumour area were lower than in the non-tumour area (P < 0.05). HAP and HAPI in the tumour area were higher than those of the non-tumour area (P < 0.05). TBF and HAP in the tumour area correlated with MVD in the tumour (P < 0.05), with correlation coefficients of 0.849 and 0.829, respectively.
CT perfusion imaging can quantitatively assess the blood supply and its distribution in liver cancer. TBF or HAP may be a useful parameter in assessing angiogenesis of liver cancer.
探讨 CT 灌注成像在评估肝癌血管生成中的价值。
对 21 例经组织学证实的肝癌患者进行 CT 灌注检查。我们比较了肿瘤区域与非肿瘤区域的以下灌注参数：总血流量（TBF）、肝动脉灌注（HAP）、肝门静脉灌注（HPP）和肝动脉灌注指数（HAPI）。术后标本切片用苏木精-伊红和抗 CD34 免疫组织化学染色。重点评估肿瘤实质中 CD34 阳性新生血管。根据 Weidner 法计算肿瘤微血管密度（MVD）。采用 Pearson 相关分析检测肿瘤 MVD 与肿瘤灌注参数之间的相关性。
肿瘤区域的 TBF 和 HPP 低于非肿瘤区域（P<0.05）。肿瘤区域的 HAP 和 HAPI 高于非肿瘤区域（P<0.05）。肿瘤区域的 TBF 和 HAP 与肿瘤中的 MVD 相关（P<0.05），相关系数分别为 0.849 和 0.829。
CT 灌注成像可定量评估肝癌的血供及其分布。TBF 或 HAP 可能是评估肝癌血管生成的有用参数。
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