Tritar Fatma, Zendah Inès, Ben M'rad Sonia, Daghfous Hafaoua
Hôpital Abderrahmane Mami de pneumo-phtysiologie, Ariana.
Tunis Med. 2009 Sep;87(9):607-9.
The Tumor Necrosis Factor is a pro-inflammatory cytokine which plays a key role in the pathogenesis of many diseases. Therefore, the anti Tumor necrosis factors have been used for treating many inflammatory pathologies such as rheumatoid arthritis or Crohn's disease with success. However, the use of these drugs has revealed during the formal years many side effects dominated by the tuberculosis. Lung cancer and asthma might be other side effects of the drugs. More recently they have been used for other pulmonary indications such as sarcoidosis. Their benefits for treating asthma is being studied. Therefore, a wise use of these drugs is mandatory to benefit from good effects and avoid hamful ones.
肿瘤坏死因子是一种促炎细胞因子，在多种疾病的发病机制中起关键作用。因此，抗肿瘤坏死因子已成功用于治疗许多炎症性疾病，如类风湿性关节炎或克罗恩病。然而，在过去几年中，这些药物的使用已显示出许多副作用，其中以结核病为主。肺癌和哮喘可能是这些药物的其他副作用。最近，它们已被用于其他肺部疾病，如结节病。它们治疗哮喘的益处正在研究中。因此，明智地使用这些药物对于获得良好效果并避免有害影响是必不可少的。
