Li Shan-Shan, Li Jian
Department of Reproduction Regulation, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University, Beijing 100026, China.
Zhonghua Nan Ke Xue. 2010 Jan;16(1):60-4.
Unexplained male infertility is mostly due to sperm-related gene mutations in the spermatogenic process. Methylenetetrahydrofolate reductase (MTHFR) plays an important role in the process of DNA, RNA and protein metabolism, and is closely related with spermatogenesis. Researchers have found more than 20 single nucleotide polymorphisms (SNP) of the MTHFR gene. The polymorphisms of MTHFRC677T and A1298C may have a close relationship with male infertility. But the correlation between MTHFRG1793 and male infertility needs to be further studied.
不明原因的男性不育大多归因于生精过程中与精子相关的基因突变。亚甲基四氢叶酸还原酶（MTHFR）在DNA、RNA和蛋白质代谢过程中发挥重要作用，且与精子发生密切相关。研究人员已发现MTHFR基因的20多个单核苷酸多态性（SNP）。MTHFRC677T和A1298C的多态性可能与男性不育密切相关。但MTHFRG1793与男性不育之间的相关性有待进一步研究。
