中卟啉基取代的 A2B-和 A3-卟啉。

meso-Pyrimidinyl-substituted A2B- and A3-corroles.

机构信息

Molecular Design and Synthesis, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.

出版信息

J Org Chem. 2010 Mar 19;75(6):2127-30. doi: 10.1021/jo902709c.

DOI:10.1021/jo902709c

PMID:20180510

Abstract

A variety of meso-pyrimidinyl-substituted A(2)B- and A(3)-corroles (A = 4,6-dichloropyrimidin-5-yl) have been synthesized by careful optimization of the macrocyclization conditions. meso-Pyrimidinylcorroles offer the distinct advantage of an unprecedented broad scope of functionalization options. Highly sterically encumbered triarylcorroles were readily prepared via efficient nucleophilic aromatic substitution and Suzuki cross-coupling procedures.

摘要

各种中-嘧啶基取代的 A(2)B-和 A(3)-corroles（A = 4,6-二氯嘧啶-5-基）已通过仔细优化大环化条件来合成。中-嘧啶基 corroles 提供了前所未有的广泛功能化选择的明显优势。通过高效的亲核芳香取代和 Suzuki 交叉偶联程序，很容易制备高度空间位阻的三芳基 corroles。