Department of Gastroenterology, The St George Hospital, University of New South Wales, Kogarah, NSW 2217, Australia.
Neurogastroenterol Motil. 2010 Jun;22(6):633-e176. doi: 10.1111/j.1365-2982.2010.01480.x. Epub 2010 Feb 24.
Colonic manometry is performed using either colonoscopically assisted catheter placement, after bowel preparation, or nasocolonic intubation of the unprepared bowel. There has been little systematic evaluation of the effects of bowel cleansing upon colonic propagating pressure wave sequences.
Eight healthy volunteers underwent nasocolonic placement of a water-perfused silicone catheter which recorded pressures at 16 recording sites each spaced 7.5 cm apart in the unprepared colon for 24 h. These measures were compared with those obtained in another eight healthy volunteers in whom the catheter was placed to the caecum at colonoscopy in the prepared colon.
The colonic motor responses to meals and morning waking, and the normal nocturnal suppression did not differ between the two groups, nor were the overall frequency, regional dependence nor extent of propagating sequences (PS) influenced by bowel preparation. Bowel preparation did result in a significant increase in the frequency of high amplitude PS (22 +/- 7 vs 8 +/- 4 HAPS/24 h; P = 0.003). Additionally, a number of the measures of spatiotemporal organization among consecutive PS (linkage among sequences and predefecatory stereotypical patterning) were significantly altered by bowel preparation.
CONCLUSIONS & INFERENCES: The overall frequency of PSs, the colonic responses to physiological stimuli such a meal and morning waking and nocturnal suppression, are not influenced by prior bowel preparation. However, investigators wishing to study HAPS frequency, or the more complex spatiotemporal relationships among consecutive PSs, should control for bowel preparation when making comparisons among study groups.
结肠测压是通过在肠道准备后经结肠镜辅助放置导管，或对未准备的肠道进行经鼻结肠插管来进行的。对于肠道清洁对结肠传播压力波序列的影响，尚未进行系统评估。
8 名健康志愿者接受了经鼻结肠放置水灌注硅酮导管的检查，该导管在未准备的结肠中 16 个记录部位以 7.5cm 的间隔记录压力，持续 24 小时。这些测量结果与另外 8 名健康志愿者的测量结果进行了比较，这些志愿者在准备好的结肠中经结肠镜将导管放置到盲肠。
两组之间的进餐和早晨醒来的结肠运动反应以及正常的夜间抑制并无差异，肠道准备也不会影响传播序列（PS）的整体频率、区域依赖性或程度。肠道准备确实导致高振幅 PS 的频率显著增加（22 ± 7 比 8 ± 4 HAPS/24 小时；P = 0.003）。此外，连续 PS 之间的时空组织的一些测量值（序列之间的联系和排便前的刻板模式）也因肠道准备而发生显著改变。
PS 的整体频率、肠道对生理刺激（如进餐和早晨醒来以及夜间抑制）的反应不受先前肠道准备的影响。然而，研究人员如果希望研究 HAPS 频率或连续 PS 之间更复杂的时空关系，则应在进行研究组之间的比较时控制肠道准备。
