原发性夜间遗尿症患者的尿糖胺聚糖排泄。
Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis.
机构信息
Department of Clinical Chemistry and Laboratory Medicine, Sevket Yilmaz Hospital, Bursa, Turkey.
出版信息
Ital J Pediatr. 2010 Feb 3;36:13. doi: 10.1186/1824-7288-36-13.
AIM
The aim of this study was to determine whether primary nocturnal enuresis (PNE) leads to alterations in glycosaminoglycan (GAG) excretion.
METHODS
Twenty subjects (mean age 8.7 years, M/F 15/5) with PNE were included in the study. Twenty-two healthy subjects were selected as a control group (mean age 8.7 years, M/F 14/8). Urinary GAG excretion was measured using a modified dimethylmethylene blue (DMD) assay of 24-hour urine.
RESULTS
The mean urinary GAG content was 33.9 mg/g and 23.8 mg/g creatinine in patients with PNE and controls, respectively; patients with PNE thus had a higher mean GAG excretion than did age-matched controls (p < 0.05). The association between GAG level and enuresis frequency bordered on significance (p = 0.068).
CONCLUSIONS
GAG excretion in patients with PNE was significantly higher than in normal children, suggesting that measurement of urinary GAG may be useful in evaluating physiopathological conditions of the bladder wall. Further studies are needed to confirm this finding.
目的
本研究旨在确定原发性夜间遗尿症（PNE）是否导致糖胺聚糖（GAG）排泄改变。
方法
研究纳入 20 例 PNE 患者（平均年龄 8.7 岁，男/女 15/5）。选择 22 例健康受试者作为对照组（平均年龄 8.7 岁，男/女 14/8）。通过 24 小时尿液的改良二甲亚甲基蓝（DMD）测定法测量尿 GAG 排泄量。
结果
PNE 患者的平均尿 GAG 含量为 33.9mg/g 和 23.8mg/g 肌酐，分别；PNE 患者的平均 GAG 排泄量高于年龄匹配的对照组（p < 0.05）。GAG 水平与遗尿频率之间存在关联（p = 0.068）。
结论
PNE 患者的 GAG 排泄量明显高于正常儿童，提示尿 GAG 测量可能有助于评估膀胱壁的生理病理状况。需要进一步的研究来证实这一发现。
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