Andrology Australia, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia.
BMC Public Health. 2010 Feb 24;10:96. doi: 10.1186/1471-2458-10-96.
The relationship between reproductive health disorders and lifestyle factors in middle-aged and older men is not clear. The aim of this study is to describe lifestyle and biomedical associations as possible causes of erectile dysfunction (ED), prostate disease (PD), lower urinary tract symptoms (LUTS) and perceived symptoms of androgen deficiency (pAD) in a representative population of middle-aged and older men, using the Men in Australia Telephone Survey (MATeS).
A representative sample (n = 5990) of men aged 40+ years, stratified by age and State, was contacted by random selection of households, with an individual response rate of 78%. All men participated in a 20-minute computer-assisted telephone interview exploring general and reproductive health. Associations between male reproductive health disorders and lifestyle and biomedical factors were analysed using multivariate logistic regression (odds ratio [95% confidence interval]). Variables studied included age, body mass index, waist circumference, smoking, alcohol consumption, physical activity, co-morbid disease and medication use for hypertension, high cholesterol and symptoms of depression.
Controlling for age and a range of lifestyle and co-morbid exposures, sedentary lifestyle and being underweight was associated with an increased likelihood of ED (1.4 [1.1-1.8]; 2.9 [1.5-5.8], respectively) and pAD (1.3 [1.1-1.7]; 2.7 [1.4-5.0], respectively. Diabetes and cardiovascular disease were both associated with ED, with hypertension strongly associated with LUTS and pAD. Current smoking (inverse association) and depressive symptomatology were the only variables independently associated with PD. All reproductive disorders showed consistent associations with depression (measured either by depressive symptomatology or medication use) in both age-adjusted and multivariate analyses.
A range of lifestyle factors, more often associated with chronic disease, were significantly associated with male reproductive health disorders. Education strategies directed to improving general health may also confer benefits to male reproductive health.
生殖健康障碍与中年和老年男性的生活方式因素之间的关系尚不清楚。本研究的目的是使用澳大利亚男性电话调查（MATeS）描述生活方式和生物医学因素与勃起功能障碍（ED）、前列腺疾病（PD）、下尿路症状（LUTS）和雄激素缺乏感知症状（pAD）之间的可能关系，该研究对象为中年和老年男性的代表性人群。
通过随机选择家庭对年龄和州分层的 40 岁以上代表性样本（n=5990）进行联系，个人应答率为 78%。所有男性均参与了一项 20 分钟的计算机辅助电话访谈，以探讨一般和生殖健康问题。使用多变量逻辑回归（比值比[95%置信区间]）分析男性生殖健康障碍与生活方式和生物医学因素之间的关系。研究的变量包括年龄、体重指数、腰围、吸烟、饮酒、体力活动、合并疾病以及高血压、高胆固醇和抑郁症状的药物治疗。
在控制年龄和一系列生活方式及合并疾病暴露因素后，久坐的生活方式和体重过轻与 ED（1.4[1.1-1.8]；2.9[1.5-5.8]）和 pAD（1.3[1.1-1.7]；2.7[1.4-5.0]）的可能性增加相关。糖尿病和心血管疾病均与 ED 相关，高血压与 LUTS 和 pAD 强烈相关。当前吸烟（负相关）和抑郁症状是唯一与 PD 独立相关的变量。所有生殖障碍在年龄调整和多变量分析中均与抑郁（通过抑郁症状或药物治疗来衡量）呈一致的关联。
一系列生活方式因素通常与慢性疾病相关，与男性生殖健康障碍显著相关。旨在改善一般健康的教育策略也可能有益于男性生殖健康。
