Champigneulle B, Braillon A, Kleber G, Gaudin C, Cailmail S, Lebrec D
Laboratoire d'Hémodynamique Splanchnique, Institut National de la Santé et de la Recherche Médicale Unité 24, Clichy, France.
Am J Physiol. 1991 Apr;260(4 Pt 1):G543-7. doi: 10.1152/ajpgi.1991.260.4.G543.
This study evaluated the hypothesis that adenosine may participate in the hemodynamic alterations observed in conscious unrestrained cirrhotic rats. In sham-operated rats, adenosine (20 micrograms.100 g body wt-1.min-1 iv) induced hyperdynamic circulation and significantly increased portal pressure, mimicking the hemodynamic changes observed in cirrhosis. Although adenosine significantly increased hyperdynamic circulation and portal pressure in cirrhotic rats, these changes were significantly less marked than in sham-operated rats. 8-Phenyltheophylline (20 micrograms.100 g body wt-1.min-1 iv), a specific and potent adenosine antagonist, significantly decreased portal tributary blood flow in sham-operated rats (-18.0 +/- 5.6%) but did not have a significant effect in cirrhotic rats. The limited effect of 8-phenyltheophylline was not due to an insufficient dose, since the dose administered antagonized the hemodynamic effect of exogenous adenosine up to 40 micrograms.100 g body wt-1.min-1. We conclude that in certain circumstances, although adenosine may aggravate the hyperdynamic circulation, in normal conditions, the hemodynamic alterations observed in cirrhotic rats are not mediated by adenosine.
本研究评估了腺苷可能参与清醒自由活动的肝硬化大鼠所观察到的血流动力学改变这一假说。在假手术大鼠中，腺苷（20微克·100克体重-1·分钟-1静脉注射）诱导了高动力循环并显著增加门静脉压力，模拟了肝硬化中观察到的血流动力学变化。尽管腺苷显著增加了肝硬化大鼠的高动力循环和门静脉压力，但这些变化比假手术大鼠中的明显程度要小得多。8-苯基茶碱（20微克·100克体重-1·分钟-1静脉注射），一种特异性强效腺苷拮抗剂，显著降低了假手术大鼠的门静脉分支血流（-18.0±5.6%），但对肝硬化大鼠没有显著影响。8-苯基茶碱的有限作用并非由于剂量不足，因为所给予的剂量能拮抗高达40微克·100克体重-1·分钟-1的外源性腺苷的血流动力学效应。我们得出结论，在某些情况下，尽管腺苷可能会加重高动力循环，但在正常情况下，肝硬化大鼠中观察到的血流动力学改变并非由腺苷介导。
