UCL Institute of Cognitive Neuroscience, University College London, WC1N 3AR London, United Kingdom.
Curr Opin Neurobiol. 2010 Apr;20(2):143-9. doi: 10.1016/j.conb.2010.01.004. Epub 2010 Feb 22.
Oscillatory fluctuations of local field potentials (LFPs) in the theta (4-8 Hz) and gamma (25-140 Hz) band are held to play a mechanistic role in various aspects of memory including the representation and off-line maintenance of events and sequences of events, the assessment of novelty, the induction of plasticity during encoding, as well as the consolidation and the retrieval of stored memories. Recent findings indicate that theta and gamma related mechanisms identified in rodent studies have significant parallels in the neurophysiology of human and non-human primate memory. This correspondence between species opens new perspectives for a mechanistic investigation of human memory function.
局部场电位(LFPs)的θ(4-8 Hz)和γ(25-140 Hz)波段的震荡波动被认为在记忆的各个方面发挥着机械作用,包括事件和事件序列的表示和离线维持、新颖性评估、编码过程中的可塑性诱导,以及存储记忆的巩固和检索。最近的发现表明,在啮齿动物研究中确定的与θ和γ相关的机制在人类和非人类灵长类动物记忆的神经生理学中具有显著的相似性。这种种间对应关系为人类记忆功能的机制研究开辟了新的视角。