希腊阻塞性睡眠呼吸障碍儿童的心脏收缩功能。

Cardiac systolic function in Greek children with obstructive sleep-disordered breathing.

机构信息

Sleep Disorders Laboratory, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece.

出版信息

Sleep Med. 2010 Apr;11(4):406-12. doi: 10.1016/j.sleep.2009.05.019. Epub 2010 Feb 23.

DOI:10.1016/j.sleep.2009.05.019

PMID:20181523

Abstract

BACKGROUND

Obstructive sleep-disordered breathing (SDB) in children has been associated with increased ventricular strain and decreased left ventricle (LV) diastolic function. The aim of this study was to assess systolic myocardial function in children with SDB of variable severity.

METHODS

Children who were referred for polysomnography during the study period underwent echocardiography (two-dimensional, Doppler and tissue Doppler imaging).

RESULTS

A total of 46 subjects (age 6.4+/-2.6years) were recruited. Fourteen of them had moderate-to-severe SDB (obstructive apnea-hypopnea index (OAHI): 16.6+/-11.6 episodes/h), 13 children had mild SDB (OAHI: 3.1+/-0.7 episodes/h) and 19 subjects had primary snoring (OAHI: 1.2+/-0.6 episodes/h). Children with moderate-to-severe SDB had significantly lower LV shortening fraction (SF) and ejection fraction (EF) than subjects with primary snoring (p<0.05). SF in moderate-to-severe SDB, mild SDB and primary snoring groups was: 34.3+/-5.5%, 36.9+/-3.2% and 37.7+/-4.4%, respectively, and EF: 66.9+/-7.9%, 71.7+/-6.4% and 72.3+/-5.9%, respectively. OAHI, age, and systolic blood pressure were significant predictors of SF and EF (p<0.01).

CONCLUSIONS

In children with obstructive SDB, LV systolic function is inversely associated with severity of intermittent upper airway obstruction during sleep.

摘要

背景

儿童阻塞性睡眠呼吸障碍（SDB）与心室应变增加和左心室（LV）舒张功能下降有关。本研究旨在评估不同严重程度 SDB 儿童的收缩期心肌功能。

方法

在研究期间，因多导睡眠图而转诊的儿童接受了超声心动图（二维、多普勒和组织多普勒成像）检查。

结果

共纳入 46 名受试者（年龄 6.4+/-2.6 岁）。其中 14 名患有中重度 SDB（阻塞性呼吸暂停低通气指数（OAHI）：16.6+/-11.6 次/小时），13 名儿童患有轻度 SDB（OAHI：3.1+/-0.7 次/小时），19 名受试者患有原发性打鼾（OAHI：1.2+/-0.6 次/小时）。中重度 SDB 患儿的左室短缩分数（SF）和射血分数（EF）明显低于原发性打鼾患儿（p<0.05）。中重度 SDB、轻度 SDB 和原发性打鼾组的 SF 分别为：34.3+/-5.5%、36.9+/-3.2%和 37.7+/-4.4%，EF 分别为：66.9+/-7.9%、71.7+/-6.4%和 72.3+/-5.9%。OAHI、年龄和收缩压是 SF 和 EF 的显著预测因子（p<0.01）。