Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary.
J Alzheimers Dis. 2010;20(3):777-83. doi: 10.3233/JAD-2010-091531.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly population. It is predicted that the incidence of AD will be increased in the future making this disease one of the greatest medical, social, and economic challenges for individuals, families, and the health care system worldwide. The etiology of AD is multifactorial. It features increased oxidative state and deposition of amyloid plaques and neurofibrillary tangles of protein tau in the central cortex and limbic system of the brain. Here we provide an overview of the positive impacts of exercise on this challenging disease. Regular physical activity increases the endurance of cells and tissues to oxidative stress, vascularization, energy metabolism, and neurotrophin synthesis, all important in neurogenesis, memory improvement, and brain plasticity. Although extensive studies are required to understand the mechanism, it is clear that physical exercise is beneficial in the prevention of AD and other age-associated neurodegenerative disorders.
阿尔茨海默病（AD）是一种影响老年人群体的进行性神经退行性疾病。预计未来 AD 的发病率将会增加，这使得该疾病成为全球个人、家庭和医疗保健系统面临的最大医学、社会和经济挑战之一。AD 的病因是多因素的。其特征在于大脑中枢皮层和边缘系统中氧化状态增加，淀粉样斑块和蛋白 tau 的神经纤维缠结沉积。在这里，我们提供了运动对这种具有挑战性的疾病的积极影响的概述。有规律的体育活动可以提高细胞和组织对氧化应激、血管生成、能量代谢和神经营养因子合成的耐受性，所有这些都对神经发生、记忆改善和大脑可塑性很重要。尽管需要进行广泛的研究来了解其机制，但很明显，体育锻炼有助于预防 AD 和其他与年龄相关的神经退行性疾病。
