Gentil B, Macquin-Mavier I, Lienhart A, Harf A
Département de Physiologie, Unité INSERM U 296, Hôpital Henri Mondor, Créteil, France.
Anesth Analg. 1991 May;72(5):612-5. doi: 10.1213/00000539-199105000-00007.
The effects of droperidol on bronchoconstriction induced by serotonin (5-HT) were studied in mechanically ventilated, paralyzed guinea pigs that had been anesthetized with pentobarbital. Droperidol did not modify the resting bronchial tone but prevented the bronchoconstrictor effects of 5-HT in a dose-related manner. Pretreatment with propranolol, hexamethonium, or prazosin did not alter the protective effects of droperidol on 5-HT-induced bronchoconstriction. The bronchoconstrictor responses to histamine or acetylcholine were not affected by droperidol. These results suggest that the protective effects of droperidol on 5-HT-induced bronchoconstriction are mediated through 5-HT receptor blockade on bronchial smooth muscle.
在经戊巴比妥麻醉、机械通气且已麻痹的豚鼠中，研究了氟哌利多对5-羟色胺（5-HT）诱导的支气管收缩的影响。氟哌利多并未改变静息支气管张力，但以剂量相关的方式阻止了5-HT的支气管收缩作用。用普萘洛尔、六甲铵或哌唑嗪预处理并未改变氟哌利多对5-HT诱导的支气管收缩的保护作用。氟哌利多对组胺或乙酰胆碱引起的支气管收缩反应没有影响。这些结果表明，氟哌利多对5-HT诱导的支气管收缩的保护作用是通过对支气管平滑肌上5-HT受体的阻断来介导的。
