From the Academic Department of Trauma and Orthopaedic Surgery, University of Leeds, Leeds, United Kingdom.
J Orthop Trauma. 2010 Mar;24 Suppl 1:S9-16. doi: 10.1097/BOT.0b013e3181cde5be.
Alteration of the bone healing process with bone morphogenetic proteins offers a new perspective in orthopaedic surgery in those adverse situations that necessitate bone grafting. BMPs have been demonstrated to be effective and safe for human application and have an efficacy comparable with that of autologous bone grafting. Nevertheless, clinical trials with level 1 evidence are still limited in their ability to extrapolate robust and safe clinical conclusions for the possible indications mentioned in this article. Future research should refine issues regarding the relative effectiveness of bone morphogenetic proteins, the interaction between bone morphogenetic protein subtypes, and their specific effect on various target cell populations.
骨形态发生蛋白改变了骨愈合过程,为需要植骨的骨科手术提供了新视角。研究表明,BMP 对人体应用既有效又安全,其疗效可与自体骨移植相媲美。然而,具有 1 级证据的临床试验仍然有限,无法为本文所述可能的适应证推断出可靠和安全的临床结论。未来的研究应解决骨形态发生蛋白的相对有效性、骨形态发生蛋白亚型之间的相互作用以及它们对各种靶细胞群体的具体作用等问题。