Branfoot Toby
Department of Trauma & Orthopaedics, St. James's University Hospital, Leeds, Beckett Str., Leeds LS9 7TF, UK.
Injury. 2005 Nov;36 Suppl 3:S51-4. doi: 10.1016/j.injury.2005.07.036.
Recently our knowledge has vastly expanded in the pathophysiological mechanisms governing the healing process of fractures. Research is ongoing in every aspect of tissue engineering and regeneration. Several molecular mediators have entered phase III clinical trials in order to evaluate their efficacy in enhancing the biological activity of fractures. Despite these developments several issues of importance remain obscured. For instance the timing of intervention, the appropriate dose of agents, the length of intervention, the routine use of available growth factors in clinical practice or not represent some of the important areas requiring further investigation. This article highlights issues relating to bone regeneration which could potentially be the focus of research in the near future.
最近，我们在骨折愈合过程的病理生理机制方面的知识有了极大的扩展。组织工程和再生的各个方面都在进行研究。几种分子介质已进入III期临床试验，以评估它们在增强骨折生物活性方面的疗效。尽管有这些进展，但仍有几个重要问题尚未明确。例如，干预时机、药物的适当剂量、干预时间、临床实践中是否常规使用现有的生长因子等，都是需要进一步研究的重要领域。本文重点介绍了与骨再生相关的问题，这些问题可能在不久的将来成为研究的焦点。
